Epigenetic Clock
An algorithm that estimates biological age or aging rate from DNA methylation patterns at specific CpG sites.
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The information provided on this page is for educational purposes only and does not constitute medical advice. Data suggests correlations, not diagnoses. Always consult a qualified healthcare professional before making health decisions based on biomarker data.
Epigenetic clocks are computational models that analyze chemical modifications to DNA (methylation) to determine biological age or aging rate. First-generation clocks (Horvath, 2013; Hannum, 2013) predicted chronological age from methylation. Second-generation clocks (PhenoAge, GrimAge) incorporated health outcomes and mortality data. Third-generation clocks like DunedinPACE measure the dynamic rate of aging rather than a static age estimate. These clocks work because DNA methylation patterns change predictably with age and are influenced by lifestyle, making them both diagnostic and responsive to intervention.— PaceSovereign Glossary
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References
- [1] Horvath S. “DNA methylation age of human tissues and cell types.” Genome Biol. 2013. doi:10.1186/gb-2013-14-10-r115